Yes. Stay alive (duh), stock up on stimpacks, do side missions to level up and get good perks like Gun Nut, have good amount of strength, charisma, intelligence, and luck, search and loot junk to have materials for settlements like lots of steel, travel and collect Power Armor (help Preston and Minutemen to help get one I think), help Brotherhood of Steel, when at Diamond City get Piper as a companion, be stocked up on Fusion Cores for Power Armor, try to stay away from Deathclaws till you're powerful enough and big Mutants and Queen Mirelurks, collect Nuka Colas and Bottlecaps of course, always fast travel to a Power Armor station to repair Power Armor before a big battle or long travels, always wear Power Armor, help Captain Ironsides at the USS Constitution (a big ship in a building) if you want, stock up on ammo, try to fight legendarys (they drop great weapons sometimes) so set game difficulty to Hard (sorry), go to 35 Court when at level 28 or higher to get XO1-Power Armor (best Power Armor).