this is actually a hard one:
You got twilight: the story of a overly protective yet sensitive vampire protecting his girlfriend/"goooooood friend". Thus getting lots of female fans cause of the male vampire and guy fans cause of the action duh.
Then there's Gears of War: the overly high-actioned series with lots of violence, a killer storyline, massive amounts of blood dropping everywhere, and one hell of a main character with a mean streak.
I would have to say Gears of war..^^