Isa: The boy's and girl's name Isa \i-sa\ is a variant of Isaac and Isaiah. Isa is a very rare male first name and a popular surname.
Sai and Isa: Isa and Sai, both mean Isvara, God, the Eternal Absolute, the Sath-Chith-Ananda (Being-Consciousness-Bliss). "Isa" is the Muslim name for Jesus, also. "Sa" means "Divine" and "All". "Ai" or "Ayi" means "Mother". Hence "Sai " means "the Divine or Supreme Mother of all. " "Sa" also means "Self-realization and visulization of the Lord - the highest stage of 'samadhi' and sadhana or spirtual practice." In addition, the name "Sai" is not a common Indian name; in fact, its origin is obscure, Professor N. Kasturi saying that it may be a derivative of the Persian word "Shah", meaning "King or Monarch"